Imaging magnetically labeled cells with magnetomotive optical coherence tomography
Optics Letters, Vol. 30, Issue 7, pp. 747-749 (2005)
http://dx.doi.org/10.1364/OL.30.000747
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Abstract
We introduce a novel contrast mechanism for optical coherence tomography (OCT) whereby the optical scattering of magnetically labeled cells is modified by means of an externally applied magnetic field. This modification is made through the addition of a small electromagnet to the imaging arm of a conventional OCT interferometer. We measure the magnetomotive OCT signal by differencing pairs of axial scans (A-scans) acquired with the magnetic field on and off. Magnetomotive contrast is demonstrated in bulk three-dimensional cell scaffolds containing macrophages labeled with microparticles of iron oxide, demonstrating magnetic-specific contrast over a dynamic range of 30 dB.
© 2005 Optical Society of America
OCIS Codes
(160.3820) Materials : Magneto-optical materials
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.5850) Scattering : Scattering, particles
Citation
Amy L. Oldenburg, Jillian R. Gunther, and Stephen A. Boppart, "Imaging magnetically labeled cells with magnetomotive optical coherence tomography," Opt. Lett. 30, 747-749 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-7-747
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