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Optics Letters

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  • Vol. 30, Iss. 9 — May. 1, 2005
  • pp: 1024–1026

Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering

Tae-Woong Koo, Selena Chan, and Andrew A. Berlin  »View Author Affiliations


Optics Letters, Vol. 30, Issue 9, pp. 1024-1026 (2005)
http://dx.doi.org/10.1364/OL.30.001024


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Abstract

We report on the applicability of combining surface-enhanced Raman scattering (SERS) with coherent anti-Stokes Raman scattering for high-sensitivity detection of biological molecules. We found that this combination of techniques provides more than 3 orders of signal enhancement compared with SERS and permits monitoring of biological molecules such as deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate at the single-molecule level. This combined technique also improved detection sensitivity for angiotensin peptide. As this is believed to be the first report of detection of dGMP at the single-molecule level, we suggest that this approach can serve as a new tool for biological studies.

© 2005 Optical Society of America

OCIS Codes
(170.7160) Medical optics and biotechnology : Ultrafast technology
(240.4350) Optics at surfaces : Nonlinear optics at surfaces
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(320.0320) Ultrafast optics : Ultrafast optics

Citation
Tae-Woong Koo, Selena Chan, and Andrew A. Berlin, "Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering," Opt. Lett. 30, 1024-1026 (2005)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-30-9-1024


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