OSA's Digital Library

Optics Letters

Optics Letters


  • Vol. 30, Iss. 9 — May. 1, 2005
  • pp: 1024–1026

Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering

Tae-Woong Koo, Selena Chan, and Andrew A. Berlin  »View Author Affiliations

Optics Letters, Vol. 30, Issue 9, pp. 1024-1026 (2005)

View Full Text Article

Acrobat PDF (93 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We report on the applicability of combining surface-enhanced Raman scattering (SERS) with coherent anti-Stokes Raman scattering for high-sensitivity detection of biological molecules. We found that this combination of techniques provides more than 3 orders of signal enhancement compared with SERS and permits monitoring of biological molecules such as deoxyguanosine monophosphate (dGMP) and deoxyadenosine monophosphate at the single-molecule level. This combined technique also improved detection sensitivity for angiotensin peptide. As this is believed to be the first report of detection of dGMP at the single-molecule level, we suggest that this approach can serve as a new tool for biological studies.

© 2005 Optical Society of America

OCIS Codes
(170.7160) Medical optics and biotechnology : Ultrafast technology
(240.4350) Optics at surfaces : Nonlinear optics at surfaces
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(320.0320) Ultrafast optics : Ultrafast optics

Tae-Woong Koo, Selena Chan, and Andrew A. Berlin, "Single-molecule detection of biomolecules by surface-enhanced coherent anti-Stokes Raman scattering," Opt. Lett. 30, 1024-1026 (2005)

Sort:  Author  |  Year  |  Journal  |  Reset


  1. K. Kneipp, Y. Wang, H. Kneipp, L. T. Perelman, I. Itzkan, R. R. Dasari, and M. S. Feld, Phys. Rev. Lett. 78, 1667 (1997). [CrossRef]
  2. S. Nie and S. R. Emory, Science 275, 1102 (1997). [CrossRef]
  3. A. Zumbusch, G. R. Holtom, and X. S. Xie, Phys. Rev. Lett. 82, 4142 (1999). [CrossRef]
  4. E. Potma, D. J. Jones, J.-X. Cheng, X. S. Xie, and J. Ye, Opt. Lett. 27, 1168 (2002).
  5. C. K. Chen, A. R. B. de Castro, Y. R. Shen, and F. DeMartini, Phys. Rev. Lett. 43, 946 (1979). [CrossRef]
  6. Y. R. Shen, Principles of Nonlinear Optics (Wiley, New York, 1984).
  7. E. J. Liang, A. Weippert, J.-M. Funk, A. Materny, and W. Kiefer, Chem. Phys. Lett. 227, 115 (1994). [CrossRef]
  8. J.-X. Cheng, L. D. Book, and X. S. Xie, Opt. Lett. 26, 1341 (2001).
  9. J. Jiang, K. Bosnick, M. Maillard, and L. Brus, J. Phys. Chem. B 107, 9964 (2003). [CrossRef]
  10. H. Xu and M. Kall, Phys. Rev. Lett. 89, 246802 (2002). [CrossRef]
  11. T.-W. Koo, S. Chan, L. Sun, X. Su, J. Zhang, and A. A. Berlin, Appl. Spectrosc. 58, 1401 (2004).
  12. P. C. Lee and D. Meisel, J. Phys. Chem. 86, 3391 (1982).
  13. K. Kneipp, H. Kneipp, V. B. Kartha, R. Manoharan, G. Deinum, I. Itzkan, R. R. Dasari, and M. S. Feld, Phys. Rev. E 57, R6281 (1998). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited