We demonstrate laser-scanning coherent anti-Stokes Raman scattering (CARS) imaging with two excitation laser beams delivered by a large-mode-area photonic crystal fiber. The group-velocity dispersion and self-phase modulation effects are largely suppressed due to the large mode area of the fiber and the use of picosecond pulses. The fiber delivery preserves the signal level and image spatial resolution well. High-quality images of live spinal cord tissues are acquired using the fiber-delivered laser source. Our method provides a basic platform for developing a flexible and compact CARS imaging system.
© 2006 Optical Society of America
Original Manuscript: January 5, 2006
Revised Manuscript: March 2, 2006
Manuscript Accepted: March 3, 2006
Vol. 1, Iss. 6 Virtual Journal for Biomedical Optics
Haifeng Wang, Terry B. Huff, and Ji-Xin Cheng, "Coherent anti-Stokes Raman scattering imaging with a laser source delivered by a photonic crystal fiber," Opt. Lett. 31, 1417-1419 (2006)