Imaging cerebral blood flow through the intact rat skull with temporal laser speckle imaging
Optics Letters, Vol. 31, Issue 12, pp. 1824-1826 (2006)
http://dx.doi.org/10.1364/OL.31.001824
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Abstract
We discovered that laser speckle temporal contrast analysis (LSTCA) is able to access the two-dimensional (2D) cerebral blood flow velocity and vessel structure through the intact rat skull. It is demonstrated that LSTCA can significantly suppress the influence of the laser speckle from the stationary structure, such as the skull, and thus reveal the blood flow and morphology of blood vessels through the laser speckle images recorded from the intact rat skull.
© 2006 Optical Society of America
OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: January 19, 2006
Revised Manuscript: April 6, 2006
Manuscript Accepted: April 6, 2006
Virtual Issues
Vol. 1, Iss. 7 Virtual Journal for Biomedical Optics
Citation
Pengcheng Li, Songlin Ni, Li Zhang, Shaoqun Zeng, and Qingming Luo, "Imaging cerebral blood flow through the intact rat skull with temporal laser speckle imaging," Opt. Lett. 31, 1824-1826 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-12-1824
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