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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 13 — Jul. 1, 2006
  • pp: 2018–2020

Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirror

Wibool Piyawattanametha, Robert P. J. Barretto, Tony H. Ko, Benjamin A. Flusberg, Eric D. Cocker, Hyejun Ra, Daesung Lee, Olav Solgaard, and Mark J. Schnitzer  »View Author Affiliations


Optics Letters, Vol. 31, Issue 13, pp. 2018-2020 (2006)
http://dx.doi.org/10.1364/OL.31.002018


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Abstract

Towards overcoming the size limitations of conventional two-photon fluorescence microscopy, we introduce two-photon imaging based on microelectromechanical systems (MEMS) scanners. Single crystalline silicon scanning mirrors that are 0.75 mm × 0.75 mm in size and driven in two dimensions by microfabricated vertical comb electrostatic actuators can provide optical deflection angles through a range of 16 ° . Using such scanners we demonstrated two-photon microscopy and microendoscopy with fast-axis acquisition rates up to 3.52 kHz .

© 2006 Optical Society of America

OCIS Codes
(110.2760) Imaging systems : Gradient-index lenses
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5810) Medical optics and biotechnology : Scanning microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 20, 2006
Revised Manuscript: March 21, 2006
Manuscript Accepted: March 28, 2006

Virtual Issues
Vol. 1, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Wibool Piyawattanametha, Robert P. J. Barretto, Tony H. Ko, Benjamin A. Flusberg, Eric D. Cocker, Hyejun Ra, Daesung Lee, Olav Solgaard, and Mark J. Schnitzer, "Fast-scanning two-photon fluorescence imaging based on a microelectromechanical systems two- dimensional scanning mirror," Opt. Lett. 31, 2018-2020 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-13-2018

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