We present a fully planar integrated optical approach to single-molecule detection based on microfabricated planar networks of intersecting solid and liquid-core waveguides. We study fluorescence from dye molecules in liquid-core antiresonant reflecting optical waveguides, and demonstrate subpicoliter excitation volumes, parallel excitation through multiple pump waveguides, and single-molecule detection sensitivity. Integrated silicon photonics combined with single-molecule detection in solution create a compact, robust, and sensitive platform that has applications in numerous fields ranging from atomic physics to the life sciences.
© 2006 Optical Society of America
Original Manuscript: February 3, 2006
Revised Manuscript: April 13, 2006
Manuscript Accepted: April 18, 2006
Vol. 1, Iss. 8 Virtual Journal for Biomedical Optics
Dongliang Yin, David W. Deamer, Holger Schmidt, John P. Barber, and Aaron R. Hawkins, "Single-molecule detection sensitivity using planar integrated optics on a chip," Opt. Lett. 31, 2136-2138 (2006)