Single-molecule detection sensitivity using planar integrated optics on a chip
Optics Letters, Vol. 31, Issue 14, pp. 2136-2138 (2006)
http://dx.doi.org/10.1364/OL.31.002136
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Abstract
We present a fully planar integrated optical approach to single-molecule detection based on microfabricated planar networks of intersecting solid and liquid-core waveguides. We study fluorescence from dye molecules in liquid-core antiresonant reflecting optical waveguides, and demonstrate subpicoliter excitation volumes, parallel excitation through multiple pump waveguides, and single-molecule detection sensitivity. Integrated silicon photonics combined with single-molecule detection in solution create a compact, robust, and sensitive platform that has applications in numerous fields ranging from atomic physics to the life sciences.
© 2006 Optical Society of America
OCIS Codes
(130.0130) Integrated optics : Integrated optics
(130.6010) Integrated optics : Sensors
(180.2520) Microscopy : Fluorescence microscopy
ToC Category:
Integrated Optics
History
Original Manuscript: February 3, 2006
Revised Manuscript: April 13, 2006
Manuscript Accepted: April 18, 2006
Virtual Issues
Vol. 1, Iss. 8 Virtual Journal for Biomedical Optics
Citation
Dongliang Yin, David W. Deamer, Holger Schmidt, John P. Barber, and Aaron R. Hawkins, "Single-molecule detection sensitivity using planar integrated optics on a chip," Opt. Lett. 31, 2136-2138 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-14-2136
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