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Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 15 — Aug. 1, 2006
  • pp: 2314–2316

Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

Mohamad G. Ghosn, Valery V. Tuchin, and Kirill V. Larin  »View Author Affiliations

Optics Letters, Vol. 31, Issue 15, pp. 2314-2316 (2006)

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We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39 ± 0.73 × 10 6 cm s at the epithelial side to 8.63 ± 0.27 × 10 6 cm s close to the endothelial side of the sclera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sclera with a resolution of approximately 40 μ m .

© 2006 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 7, 2006
Revised Manuscript: May 8, 2006
Manuscript Accepted: May 15, 2006
Published: July 10, 2006

Virtual Issues
Vol. 1, Iss. 9 Virtual Journal for Biomedical Optics

Mohamad G. Ghosn, Valery V. Tuchin, and Kirill V. Larin, "Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography," Opt. Lett. 31, 2314-2316 (2006)

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  1. V. V. Tuchin, Optical Clearing of Tissues and Blood, Vol. 154 of Press Monograph Series (SPIE, 2005). [CrossRef]
  2. M. R. Prausnitz and J. S. Noonan, J. Pharm. Sci. 87, 1479 (1998). [CrossRef]
  3. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, Science 254, 1178 (1991). [CrossRef] [PubMed]
  4. A. Edwards and M. R. Prausnitz, AIChE J. 44, 214 (1998). [CrossRef]
  5. Y. Komai and T. Ushiki, Invest. Ophthalmol. Visual Sci. 32, 2244 (1991).
  6. R. O. Esenaliev, K. V. Larin, I. V. Larina, and M. Motamedi, Opt. Lett. 26, 992 (2001). [CrossRef]
  7. V. V. Tuchin, J. Phys. D 38, 2497 (2005). [CrossRef]
  8. W. Verkruysse, M. Khan, B. Choi, L. O. Svaasand, and J. S. Nelson, in Proc. SPIE 5695, 278 (2005). [CrossRef]
  9. A. N. Bashkatov, E. A. Genina, Y. P. Sinichkin, V. I. Kochubei, N. A. Lakodina, and V. V. Tuchin, Biophysics (Engl. Transl.) 48, 292 (2003).

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