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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 19 — Oct. 1, 2006
  • pp: 2876–2878

Endoscopic, rapid near-infrared optical tomography

Daqing Piao, Hao Xie, Weili Zhang, Jerzy S. Krasinski, Guolong Zhang, Hamid Dehghani, and Brian W. Pogue  »View Author Affiliations

Optics Letters, Vol. 31, Issue 19, pp. 2876-2878 (2006)

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This is believed to be the first demonstration of near-infrared (NIR) optical tomography employed at the endoscope scale and at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source and linear-to-circular fiber bundling was used to provide endoscopic probing of many source–detector fibers for tomography as well as parallel sampling of all source–detector pairs for rapid imaging. Endoscopic NIR tomography at an 8 Hz frame rate was achieved in phantoms and tissue specimens with a 12 mm probe housing eight sources and eight detectors. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be attempted in detection of cancer in internal organs via endoscopic interrogation.

© 2006 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: May 23, 2006
Revised Manuscript: June 27, 2006
Manuscript Accepted: July 11, 2006
Published: September 11, 2006

Virtual Issues
Vol. 1, Iss. 11 Virtual Journal for Biomedical Optics

Daqing Piao, Hao Xie, Weili Zhang, Jerzy S. Krasinski, Guolong Zhang, Hamid Dehghani, and Brian W. Pogue, "Endoscopic, rapid near-infrared optical tomography," Opt. Lett. 31, 2876-2878 (2006)

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  1. M. A. Franceschini, K. T. Moesta, S. Fantini, G. Gaida, E. Gratton, H. Jess, W. W. Mantulin, M. Seeber, P. M. Schlag, and M. Kaschke, Proc. Natl. Acad. Sci. U.S.A. 94, 6468 (1997). [CrossRef] [PubMed]
  2. B. J. Tromberg, O. Coquoz, J. B. Fishkin, T. Pham, E. R. Anderson, J. Butler, M. Cahn, J. D. Gross, V. Venugopalan, and D. Pham, Philos. Trans. R. Soc. London, Ser. B 352, 661 (1997). [CrossRef] [PubMed]
  3. B. W. Pogue, S. P. Poplack, T. O. McBride, W. A. Wells, K. S. Osterman, U. L. Osterberg, and K. D. Paulsen, Radiology 218, 261 (2001). [PubMed]
  4. V. Ntziachristos, A. G. Yodh, M. D. Schnall, and B. Chance, Neoplasia 4, 347 (2002). [CrossRef] [PubMed]
  5. M. R. Arnfield, J. D. Chapman, J. Tulip, M. C. Fenning, and M. S. McPhee, Photochem. Photobiol. 57, 306 (1993). [CrossRef] [PubMed]
  6. T. Zhu, A. Dimofte, J. C. Finlay, D. Stripp, T. Busch, J. Miles, R. Whittington, S. B. Malkowicz, Z. Tochner, E. Glatstein, and S. M. Hahn, Phys. Plasmas 81, 96 (2005).
  7. M. Goel, H. Radhakrishnan, and H. Liu, paper SH10 presented at the OSA Biomedical Topical Meetings, Fort Lauderdale, Florida, March 19-22, 2006.
  8. A. K. Scheel, M. Backhaus, A. D. Klose, B. Moa-Anderson, U. Netz, K. G. Hermann, J. Beuthan, G. A. Müller, G. R. Burmester, and A. H. Hielscher, Ann. Rheum. Dis. 64, 239 (2005). [CrossRef]
  9. C. H. Schmitz, M. Löcker, J. M. Lasker, A. H. Hielscher, and R. L. Barbour, Rev. Sci. Instrum. 73, 429 (2002). [CrossRef]
  10. D. Piao, S. Jiang, S. Srinivasan, H. Dehghani, and B. W. Pogue, Opt. Lett. 30, 2593 (2005). [CrossRef] [PubMed]
  11. D. Piao, H. Dehghani, S. Jiang, S. Srinivasan, and B. W. Pogue, Rev. Sci. Instrum. 76, 124301 (2005). [CrossRef]
  12. http://www-nml.dartmouth.edu/nir/downloads.html.

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