We present theoretical calculations, based on a random phasor sum model, which show that the optical coherence tomography speckle contrast ratio is dependent on the local density of scattering particles in a sample, provided that the effective number of scatterers in the probed volume is less than about five. We confirm these theoretical predictions experimentally, using suspensions of microspheres in water. The observed contrast ratios vary in value from the Rayleigh limit of 0.52 to in excess of 2, suggesting that the contrast ratio could be useful in optical coherence tomography, particularly when imaging in ultrahigh-resolution regimes.
© 2006 Optical Society of America
Medical Optics and Biotechnology
Vol. 1, Iss. 2 Virtual Journal for Biomedical Optics
Timothy R. Hillman, Steven G. Adie, Volker Seemann, Julian J. Armstrong, Steven L. Jacques, and David D. Sampson, "Correlation of static speckle with sample properties in optical coherence tomography," Opt. Lett. 31, 190-192 (2006)