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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 21 — Nov. 1, 2006
  • pp: 3119–3121

Assessing epithelial cell nuclear morphology by using azimuthal light scattering spectroscopy

Chung-Chieh Yu, Condon Lau, James W. Tunnell, Martin Hunter, Maxim Kalashnikov, Christopher Fang-Yen, Stephen F. Fulghum, Kamran Badizadegan, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations


Optics Letters, Vol. 31, Issue 21, pp. 3119-3121 (2006)
http://dx.doi.org/10.1364/OL.31.003119


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Abstract

We describe azimuthal light scattering spectroscopy ( ϕ LSS ) , a novel technique for assessing epithelial-cell nuclear morphology. The difference between the spectra measured at azimuthal angles ϕ = 0 ° and ϕ = 90 ° preferentially isolates the single backscattering contribution due to large ( 10 μ m ) structures such as epithelial cell nuclei by discriminating against scattering from smaller organelles and diffusive background. We demonstrate the feasibility of using ϕ LSS for cancer detection by showing that spectra from cancerous colon tissue exhibit significantly greater azimuthal asymmetry than spectra from normal colonic tissues.

© 2006 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.0290) Scattering : Scattering

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 30, 2006
Manuscript Accepted: July 21, 2006
Published: October 11, 2006

Virtual Issues
Vol. 1, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Chung-Chieh Yu, Condon Lau, James W. Tunnell, Martin Hunter, Maxim Kalashnikov, Christopher Fang-Yen, Stephen F. Fulghum, Kamran Badizadegan, Ramachandra R. Dasari, and Michael S. Feld, "Assessing epithelial cell nuclear morphology by using azimuthal light scattering spectroscopy," Opt. Lett. 31, 3119-3121 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-21-3119

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