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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 23 — Dec. 1, 2006
  • pp: 3459–3461

Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography

A. D. Aguirre, Y. Chen, J. G. Fujimoto, L. Ruvinskaya, A. Devor, and D. A. Boas  »View Author Affiliations

Optics Letters, Vol. 31, Issue 23, pp. 3459-3461 (2006)

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Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.

© 2006 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.5380) Medical optics and biotechnology : Physiology

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 16, 2006
Revised Manuscript: September 7, 2006
Manuscript Accepted: September 7, 2006
Published: November 9, 2006

Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics

A. D. Aguirre, Y. Chen, J. G. Fujimoto, L. Ruvinskaya, A. Devor, and D. A. Boas, "Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography," Opt. Lett. 31, 3459-3461 (2006)

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