Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography
Optics Letters, Vol. 31, Issue 23, pp. 3459-3461 (2006)
http://dx.doi.org/10.1364/OL.31.003459
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Abstract
Co-registered optical coherence tomography (OCT) and video microscopy of the rat somatosensory cortex were acquired simultaneously through a thinned skull during forepaw electrical stimulation. Fractional signal change measured by OCT revealed a functional signal time course corresponding to the hemodynamic signal measurement made with video microscopy. OCT can provide high-resolution, cross-sectional images of functional neurovascular activation and may offer a new tool for basic neuroscience research in the important rat cerebral cortex model.
© 2006 Optical Society of America
OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.5380) Medical optics and biotechnology : Physiology
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: June 16, 2006
Revised Manuscript: September 7, 2006
Manuscript Accepted: September 7, 2006
Published: November 9, 2006
Virtual Issues
Vol. 2, Iss. 1 Virtual Journal for Biomedical Optics
Citation
A. D. Aguirre, Y. Chen, J. G. Fujimoto, L. Ruvinskaya, A. Devor, and D. A. Boas, "Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography," Opt. Lett. 31, 3459-3461 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-23-3459
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