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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 3 — Feb. 1, 2006
  • pp: 365–367

Spectrally resolved bioluminescence optical tomography

Hamid Dehghani, Scott C. Davis, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen, and Michael S. Patterson  »View Author Affiliations

Optics Letters, Vol. 31, Issue 3, pp. 365-367 (2006)

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Spectrally resolved bioluminescence optical tomography is an approach to recover images of luciferase activity within a volume using multiwavelength emission data from internal bioluminescence sources. The underlying problem of uniqueness associated with nonspectrally resolved intensity-based bioluminescence tomography is highlighted. Reconstructed images of bioluminescence are presented by using as input both simulated and real multiwavelength data from a tissue-simulating phantom. The location of the internal bioluminescence is obtained with 1 mm accuracy. Further, the amplitude of the reconstructed source is proportional to the actual bioluminescence intensity.

© 2006 Optical Society of America

OCIS Codes
(100.3010) Image processing : Image reconstruction techniques
(110.6960) Imaging systems : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 16, 2005
Revised Manuscript: October 13, 2005
Manuscript Accepted: October 22, 2005

Virtual Issues
Vol. 1, Iss. 3 Virtual Journal for Biomedical Optics

Hamid Dehghani, Scott C. Davis, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen, and Michael S. Patterson, "Spectrally resolved bioluminescence optical tomography," Opt. Lett. 31, 365-367 (2006)

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