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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 4 — Feb. 15, 2006
  • pp: 474–476

Improved in vivo photoacoustic microscopy based on a virtual-detector concept

Meng-Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica, and Lihong V. Wang  »View Author Affiliations

Optics Letters, Vol. 31, Issue 4, pp. 474-476 (2006)

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Recently an in vivo high-resolution backward-mode photoacoustic microscope was developed that shows potential for applications in dermatology and related cancer research. However, the limited depth of focus of the large-numerical-aperture (NA) ultrasonic lens employed in this system causes the image quality to deteriorate significantly in the out-of-focus region. To solve this problem, we devised and explored, for the first time to our knowledge, a virtual-detector-based synthetic-aperture focusing technique, combined with coherence weighting, for photoacoustic microscopy with such a large-NA transducer. Images of phantoms show that the proposed technique improves the 6 dB lateral resolution from 49 379 to 46 53 μ m and increases the signal-to-noise ratio by up to 29 dB , depending on the distance from the ultrasonic focal point. In vivo experiments show that the technique also provides a clearer representation of the vascular distribution in the rat’s scalp.

© 2006 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 18, 2005
Revised Manuscript: October 18, 2005
Manuscript Accepted: November 4, 2005

Virtual Issues
Vol. 1, Iss. 3 Virtual Journal for Biomedical Optics

Meng-Lin Li, Hao F. Zhang, Konstantin Maslov, George Stoica, and Lihong V. Wang, "Improved in vivo photoacoustic microscopy based on a virtual-detector concept," Opt. Lett. 31, 474-476 (2006)

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