OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 6 — Mar. 15, 2006
  • pp: 769–771

Comparison of noncontact and fiber-based fluorescence-mediated tomography

Ralf B. Schulz, Jörg Peter, Wolfhard Semmler, Cosimo D’Andrea, Gianluca Valentini, and Rinaldo Cubeddu  »View Author Affiliations

Optics Letters, Vol. 31, Issue 6, pp. 769-771 (2006)

View Full Text Article

Enhanced HTML    Acrobat PDF (325 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We present a comparative experimental phantom study of fiber-based and noncontact fluorescence tomography with respect to quantitation and localization of reconstructed fluorescent inclusions in turbid media such as tissue. Noncontact acquisition is usually considered potentially superior to fiber-based techniques because of the availability of a large number of detector readouts through a CCD. Our results indicate, however, that noncontact acquisition itself might improve the quality of reconstructions significantly, even without increasing the number of detectors and thus keeping the inverse problem moderately complex.

© 2006 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6960) Medical optics and biotechnology : Tomography
(170.7050) Medical optics and biotechnology : Turbid media
(260.2510) Physical optics : Fluorescence

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 23, 2005
Revised Manuscript: December 1, 2005
Manuscript Accepted: December 4, 2005

Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics

Ralf B. Schulz, Jörg Peter, Wolfhard Semmler, Cosimo D'Andrea, Gianluca Valentini, and Rinaldo Cubeddu, "Comparison of noncontact and fiber-based fluorescence-mediated tomography," Opt. Lett. 31, 769-771 (2006)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. V. Ntziachristos, C. Bremer, E. E. Graves, J. Ripoll, and R. Weissleder, Molecular Imaging 1, 82 (2005). [CrossRef]
  2. J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, A. Slemp, V. Ntziachristos, B. Chance, and A. G. Yodh, Med. Phys. 30, 235 (2003). [CrossRef] [PubMed]
  3. E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, Med. Phys. 30, 901 (2003). [CrossRef] [PubMed]
  4. J. P. Culver, T. Durduran, D. Furuya, C. Cheung, J. H. Greenberg, and A. G. Yodh, J. Cereb. Blood Flow Metab. 23, 911 (2003). [CrossRef] [PubMed]
  5. J. Ripoll, R. B. Schulz, and V. Ntziachristos, Phys. Rev. Lett. 91, 103901 (2003). [CrossRef] [PubMed]
  6. R. B. Schulz, J. Ripoll, and V. Ntziachristos, IEEE Trans. Med. Imaging 23, 492 (2004). [CrossRef] [PubMed]
  7. V. Ntziachristos and R. Weissleder, Opt. Lett. 26, 893 (2001). [CrossRef]
  8. M. Schweiger, S. R. Arridge, M. Hiraoka, and D. T. Delpy, Med. Phys. 22, 1779 (1995). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3
Fig. 4

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited