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  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 6 — Mar. 15, 2006
  • pp: 775–777

Diffraction phase microscopy for quantifying cell structure and dynamics

Gabriel Popescu, Takahiro Ikeda, Ramachandra R. Dasari, and Michael S. Feld  »View Author Affiliations


Optics Letters, Vol. 31, Issue 6, pp. 775-777 (2006)
http://dx.doi.org/10.1364/OL.31.000775


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Abstract

We have developed diffraction phase microscopy as a new technique for quantitative phase imaging of biological structures. The method combines the principles of common path interferometry and single-shot phase imaging and is characterized by subnanometer path-length stability and millisecond-scale acquisition time. The potential of the technique for quantifying nanoscale motions in live cells is demonstrated by experiments on red blood cells.

© 2006 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1530) Medical optics and biotechnology : Cell analysis
(180.0180) Microscopy : Microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 23, 2005
Revised Manuscript: November 12, 2005
Manuscript Accepted: December 5, 2005

Virtual Issues
Vol. 1, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Gabriel Popescu, Takahiro Ikeda, Ramachandra R. Dasari, and Michael S. Feld, "Diffraction phase microscopy for quantifying cell structure and dynamics," Opt. Lett. 31, 775-777 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-6-775


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