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Optics Letters

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  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 7 — Apr. 1, 2006
  • pp: 927–929

Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography

Hongwu Ren, Tao Sun, Daniel J. MacDonald, Michael J. Cobb, and Xingde Li  »View Author Affiliations


Optics Letters, Vol. 31, Issue 7, pp. 927-929 (2006)
http://dx.doi.org/10.1364/OL.31.000927


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Abstract

We present a moving-scatterer-sensitive optical Doppler tomography (MSS-ODT) technique for in vivo blood flow imaging in real time by using a spectral-domain optical coherence tomography system. In MSS-ODT the influence of stationary scatterers is suppressed by subtracting adjacent complex axial scans before calculating the Doppler frequency shift. We demonstrate that MSS-ODT is a useful technique for accurate determination of blood vessel size by imaging flow in a small capillary tube with a 75 μ m inner diameter. The flow profile obtained with MSS-ODT yields a substantially more accurate tube diameter than that obtained with the conventional phase-resolved method, which underestimates the diameter by about 23%. We also demonstrate that MSS-ODT provides improved sensitivity over the conventional phase-resolved method for imaging in vivo blood flow in small vessels in a mouse ear.

© 2006 Optical Society of America

OCIS Codes
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 14, 2005
Manuscript Accepted: January 2, 2006

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Hongwu Ren, Tao Sun, Daniel J. MacDonald, Michael J. Cobb, and Xingde Li, "Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography," Opt. Lett. 31, 927-929 (2006)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-31-7-927


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