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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 31, Iss. 8 — Apr. 15, 2006
  • pp: 1082–1084

Feasibility of diffuse optical imaging with long-lived luminescent probes

Sofia V. Apreleva, David F. Wilson, and Sergei A. Vinogradov  »View Author Affiliations

Optics Letters, Vol. 31, Issue 8, pp. 1082-1084 (2006)

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Long-lived near-infrared phosphors with high quantum yields have recently become available, making it possible to image oxygen distributions in tissue in three dimensions. By numerical simulations we demonstrate that, by using phosphorescent probes with appropriate oxygen quenching constants, one can image hypoxic phantoms in scattering media with adequate spatial resolution, employing simple time-gated measurements. The approach developed will guide experimental imaging of phosphorescence lifetime and oxygen pressure in living tissue.

© 2006 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(290.0290) Scattering : Scattering
(290.7050) Scattering : Turbid media

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: September 21, 2005
Revised Manuscript: January 10, 2006
Manuscript Accepted: January 17, 2006

Virtual Issues
Vol. 1, Iss. 5 Virtual Journal for Biomedical Optics

Sofia V. Apreleva, David F. Wilson, and Sergei A. Vinogradov, "Feasibility of diffuse optical imaging with long-lived luminescent probes," Opt. Lett. 31, 1082-1084 (2006)

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  12. Optical parameters of the prototype probe, Pd tetrabenzoporphyrin dendrimer: λmax(abs)=636nm, ϵ=82,000M−1cm−1, λmax(emiss)=810nm, phivphos=0.2, Kq=718mmHg−1s−1, τ0=246μs.
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  14. SNR here is defined as the ratio of the signal at the start of the decay (before integration) to the amplitude of the noise. The SNR of a data set (decays for all source-detector pairs) is the SNR of the decay with maximal initial intensity. In the shot-noise limit and for the model experiment described, a SNR of 50 can easily be achieved by use of, e.g., 1μs excitation pulses of 1W LED and detection over an ∼5mm2 boundary area.
  15. S. A. Vinogradov and D. F. Wilson, Appl. Spectrosc. 54, 849 (2000). [CrossRef]

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