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Optics Letters

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  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 12 — Jun. 15, 2007
  • pp: 1674–1676

Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture

Larry K. Wong, Michael J. Mandella, Gordon S. Kino, and Thomas D. Wang  »View Author Affiliations


Optics Letters, Vol. 32, Issue 12, pp. 1674-1676 (2007)
http://dx.doi.org/10.1364/OL.32.001674


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Abstract

We perform Monte Carlo simulations to show that the dual-axes (DA) confocal architecture has superior rejection of multiply scattered photons in tissue to that of single axis. As a result, the DA configuration provides improved signal-to-noise ratio and dynamic range, and thus is sensitive to ballistic photons from deeper within tissue, features that are particularly useful for performing vertical cross-sectional reflectance images in tissue.

© 2007 Optical Society of America

OCIS Codes
(170.0180) Medical optics and biotechnology : Microscopy
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.5280) Medical optics and biotechnology : Photon migration
(170.6930) Medical optics and biotechnology : Tissue
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 2, 2007
Revised Manuscript: March 30, 2007
Manuscript Accepted: April 20, 2007
Published: June 5, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Larry K. Wong, Michael J. Mandella, Gordon S. Kino, and Thomas D. Wang, "Improved rejection of multiply scattered photons in confocal microscopy using dual-axes architecture," Opt. Lett. 32, 1674-1676 (2007)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-12-1674


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References

  1. D. L. Dickensheets and G. S. Kino, Opt. Lett. 21, 764 (1996). [CrossRef] [PubMed]
  2. D. Yelin, I. Rizvi, W. M. White, J. T. Motz, T. Hasan, B. E. Bouma, and G. J. Tearney, Nature 443, 765 (2006). [CrossRef] [PubMed]
  3. R. H. Webb and F. Rogomentich, Appl. Opt. 38, 4870 (1999). [CrossRef]
  4. T. D. Wang, M. J. Mandella, C. H. Contag, N. Y. Chan, and G. S. Kino, Opt. Lett. 28, 414 (2003). [CrossRef] [PubMed]
  5. T. D. Wang, C. H. Contag, M. J. Mandella, N. Y. Chan, and G. S. Kino, Opt. Lett. 28, 1915 (2003). [CrossRef] [PubMed]
  6. J. T. C. Liu, M. J. Mandella, S. Friedland, R. Soetikno, J. H. Crawford, C. H. Contag, G. S. Kino, and T. D. Wang, J. Biomed. Opt. 11, 054019 (2006). [CrossRef] [PubMed]
  7. S. Prahl, 'Mie scattering calculator,' http://omlc.ogi.edu/calc/mielowbarcalc.html.
  8. C. Bohren and D. Huffman, Absorption and Scattering of Light by Small Particles (Wiley, 1983).
  9. L. Henyey and J. Greenstein, Astrophys. J. 93, 70 (1941). [CrossRef]
  10. S. A. Prahl, M. Keijzer, S. L. Jacques, and A. J. Welch, Proc. SPIE 5, 102 (1989).
  11. R. Bays, G. Wagnieres, D. Robert, D. Braichotte, J.-F. Savary, P. Monnier, and H. van den Bergh, Appl. Opt. 35, 1756 (1996). [CrossRef] [PubMed]

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