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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 16 — Aug. 15, 2007
  • pp: 2285–2287

Multi-optical-wavelength ultrasound-modulated optical tomography: a phantom study

Chulhong Kim and Lihong V. Wang  »View Author Affiliations

Optics Letters, Vol. 32, Issue 16, pp. 2285-2287 (2007)

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We used multiple optical wavelengths to study ultrasound-modulated optical tomography (UOT) in tissue phantoms. By using intense acoustic bursts and a CCD camera-based speckle contrast detection technique, we observed variations of the ultrasound-modulated signal at various optical absorptions. The experimental variations were found to be highly correlated with predictions from Monte Carlo simulations. By irradiating the sample at two optical wavelengths, we quantitatively estimated the total concentration and the concentration ratio of double dyes in objects embedded in tissue phantoms. The results suggest that UOT can potentially provide noninvasive functional imaging of the total concentration and oxygen saturation of hemoglobin in biological tissue.

© 2007 Optical Society of America

OCIS Codes
(030.1670) Coherence and statistical optics : Coherent optical effects
(110.6150) Imaging systems : Speckle imaging
(110.7170) Imaging systems : Ultrasound
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 12, 2007
Revised Manuscript: July 2, 2007
Manuscript Accepted: July 6, 2007
Published: August 2, 2007

Virtual Issues
Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Chulhong Kim and Lihong V. Wang, "Multi-optical-wavelength ultrasound-modulated optical tomography: a phantom study," Opt. Lett. 32, 2285-2287 (2007)

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