OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Anthony J. Campilo
  • Vol. 32, Iss. 17 — Sep. 1, 2007
  • pp: 2541–2543

Real-time detection of DNA interactions with long-period fiber-grating-based biosensor

Xianfeng Chen, Lin Zhang, Kaiming Zhou, Edward Davies, Kate Sugden, Ian Bennion, Marcus Hughes, and Anna Hine  »View Author Affiliations

Optics Letters, Vol. 32, Issue 17, pp. 2541-2543 (2007)

View Full Text Article

Enhanced HTML    Acrobat PDF (257 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Using an optical biosensor based on a dual-peak long-period fiber grating, we have demonstrated the detection of interactions between biomolecules in real time. Silanization of the grating surface was successfully realized for the covalent immobilization of probe DNA, which was subsequently hybridized with the complementary target DNA sequence. It is interesting to note that the DNA biosensor was reusable after being stripped off the hybridized target DNA from the grating surface, demonstrating a function of multiple usability.

© 2007 Optical Society of America

OCIS Codes
(050.2770) Diffraction and gratings : Gratings
(060.2370) Fiber optics and optical communications : Fiber optics sensors

ToC Category:
Fiber Optics and Optical Communications

Original Manuscript: May 17, 2007
Revised Manuscript: July 13, 2007
Manuscript Accepted: July 14, 2007
Published: August 20, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

Xianfeng Chen, Lin Zhang, Kaiming Zhou, Edward Davies, Kate Sugden, Ian Bennion, Marcus Hughes, and Anna Hine, "Real-time detection of DNA interactions with long-period fiber-grating-based biosensor," Opt. Lett. 32, 2541-2543 (2007)

Sort:  Year  |  Journal  |  Reset  


  1. H. R. Luckarift, J. C. Spain, R. R. Naik, and M. O. Stone, Nat. Biotechnol. 22, 211 (2004). [CrossRef] [PubMed]
  2. M. Beier and J. D. Hoheisel, Nucleic Acids Res. 27, 1970 (1999). [CrossRef] [PubMed]
  3. F. Vollmer, D. Braun, and A. Libchaber, Appl. Phys. Lett. 80, 4057 (1995). [CrossRef]
  4. A. Ksendzov and Y. Lin, Opt. Lett. 30, 3344 (2005). [CrossRef]
  5. J. L. DeRisi, V. R. Iver, and P. O. Brown, Science 278, 680 (1997). [CrossRef] [PubMed]
  6. G. Boisde and A. Harmer, Chemical and Biochemical Sensing with Optical Fibers and Waveguides (Artech House, 1996).
  7. M. P. DeLisa, Z. Zhang, M. Shiloach, S. Pilevar, C. C. Davis, J. S. Sirkis, and W. E. Bentley, Anal. Chem. 72, 2895 (2000). [CrossRef] [PubMed]
  8. A. N. Chryssis, S. S. Saini, S. M. Lee, H. Yi, W. E. Bentley, and M. Dagenais, IEEE J. Sel. Top. Quantum Electron. 11, 864 (2005). [CrossRef]
  9. X. Shu, L. Zhang, and I. Bennion, J. Lightwave Technol. 20, 255 (2002). [CrossRef]
  10. X. Chen, K. Zhou, L. Zhang, and I. Bennion, Appl. Opt. 46, 451 (2007). [CrossRef] [PubMed]
  11. G. T. Hermanson, Bioconjugate Techniques (Academic, 1996).
  12. G. Mattson, E. Conklin, S. Desai, G. Nielander, D. Savage, and S. Morgensen, Mol. Biol. Rep. 17, 167 (1993). [CrossRef] [PubMed]
  13. S. L. Rea, D. Wu, J. R. Cypser, J. W. Vaupel, and T. E. Johnson, Nat. Genet. 37, 894 (2005). [CrossRef] [PubMed]
  14. M. D. Hughes, Z. R. Zhang, A. J. Sutherland, A. F. Santos, and A. V. Hine, Nucleic Acids Res. 33, e32 (2005). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3
Fig. 4 Fig. 5

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited