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Tomographic imaging of absolute optical absorption coefficient in turbid media using combined photoacoustic and diffusing light measurements

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Abstract

We present a new method that can provide high resolution images of absolute optical absorption coefficient in heterogeneous turbid media. In this method, acoustic measurements in conventional photoacoustic tomography are combined with diffusing light measurements to separate the product of absorption coefficient and optical fluence or photon density. We validate this method using a series of tissuelike phantom experiments. The experimental results show that targets as small as 0.5mm in diameter with optical absorption contrasts as low as 1.5 relative to a 50mm diameter scattering background medium can be clearly detected.

© 2007 Optical Society of America

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