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Optics Letters

Optics Letters


  • Editor: Anthony J. Campilo
  • Vol. 32, Iss. 17 — Sep. 1, 2007
  • pp: 2614–2616

Functional optical coherence tomography reveals localized layer-specific activations in cat primary visual cortex in vivo

Uma Maheswari Rajagopalan and Manabu Tanifuji  »View Author Affiliations

Optics Letters, Vol. 32, Issue 17, pp. 2614-2616 (2007)

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Surface neural activity has been widely visualized using optical intrinsic signal imaging (OISI) from various cortical sensory areas. OISI of the cortical surface with a CCD camera gives integrated information across a depth of a few hundred micrometers. We visualize depth-resolved activation patterns of cat primary visual cortex by functional optical coherence tomography (fOCT). A comparison of the depth-integrated results of fOCT maps with the optical intrinsic signal profiles shows fairly good agreement. Our results reveal layer-specific activation patterns and indicate that the activation was not homogeneous.

© 2007 Optical Society of America

OCIS Codes
(000.1430) General : Biology and medicine
(030.5290) Coherence and statistical optics : Photon statistics
(110.1650) Imaging systems : Coherence imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(330.4270) Vision, color, and visual optics : Vision system neurophysiology
(330.4300) Vision, color, and visual optics : Vision system - noninvasive assessment

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 19, 2007
Revised Manuscript: June 13, 2007
Manuscript Accepted: June 21, 2007
Published: August 28, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

Uma Maheswari Rajagopalan and Manabu Tanifuji, "Functional optical coherence tomography reveals localized layer-specific activations in cat primary visual cortex in vivo," Opt. Lett. 32, 2614-2616 (2007)

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  1. T. Bonhoeffer, A. Grinvald, in Brain Mapping-The Methods, A.W.Toga and J.C.Mazziotta, eds. (Academic, 1996), pp. 55-97.
  2. D. Y. Ts'o, R. D. Frostig, E. E. Leike, and A. Grinvald, Science 249, 417 (1990). [CrossRef] [PubMed]
  3. M. Tanifuji, in The Primate Visual System, J.H.Kaas and C.E.Collins, eds. (CRC, 2004), pp. 345-363.
  4. D. H. Hubel, Eye, Brain and Vision (Scientific American Library, 1995).
  5. B. E. Bouma and G. J. Tearney, Handbook Of Optical Cohrence Tomography (Marcel Dekker, 2002).
  6. R. Uma Maheswari, H. Takaoka, H. Kadono, R. Homma, and M. Tanifuji, J. Neurosci. Methods 124, 83 (2003). [CrossRef] [PubMed]
  7. R. Uma Maheswari, H. Kadono, R. Homma, and M. Tanifuji, Proc. SPIE 5140, 77 (2003). [CrossRef]
  8. M. Lazebnik, D. L. Marks, K. Potgieter, R. Gillette, and S. A. Boppart, Opt. Lett. 28, 1218 (2003). [CrossRef] [PubMed]
  9. X.-C. Yao, A. Yamauchi, B. Perry, and J. S. George, Appl. Opt. 44, 2019 (2005). [CrossRef] [PubMed]
  10. K. Bizheva, R. Pflug, B. Hermann, B. Povazay, H. Sattmann, P. Qiu, E. Anger, H. Reitsamer, S. Popov, J. R. Taylor, A. Unterhuber, P. Ahnelt, and W. Drexler, Proc. Natl. Acad. Sci. 103, 5066 (2006). [CrossRef] [PubMed]
  11. V. J. Srinivasan, M. Wojtkowski, J. G. Fujimoto, and J. S. Duker, Opt. Lett. 31, 2308 (2006). [CrossRef] [PubMed]
  12. A. D. Aguirre, Y. Chen, J. G. Fujimoto, L. Ruvinskaya, A. Devor, and D. A. Boas, Opt. Lett. 31, 3459 (2006). [CrossRef] [PubMed]
  13. T. Bonhoeffer and A. Grinvald, J. Neurosci. 13, 4157 (1993). [PubMed]

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