OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 20 — Oct. 15, 2007
  • pp: 3002–3004

Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis

Xueding Wang, David L. Chamberland, and David A. Jamadar  »View Author Affiliations

Optics Letters, Vol. 32, Issue 20, pp. 3002-3004 (2007)

View Full Text Article

Enhanced HTML    Acrobat PDF (348 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



The feasibility of photoacoustic tomography (PAT) in imaging human peripheral joints in a noninvasive manner was demonstrated through studies of cadaver human fingers. Based on the intrinsic optical contrast, intra- and extra-articular tissue structures in the finger at the levels of the joints were visualized successfully with satisfactory spatial resolution. The imaging depth of PAT in the near-infrared region enables the cross-sectional imaging of a human finger as a whole organ. As a novel technology with unique advantages, PAT holds promise for early diagnosis of inflammatory joint disorders and accurate monitoring of disease progression and response to therapy.

© 2007 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 10, 2007
Manuscript Accepted: August 15, 2007
Published: October 9, 2007

Virtual Issues
Vol. 2, Iss. 11 Virtual Journal for Biomedical Optics

Xueding Wang, David L. Chamberland, and David A. Jamadar, "Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis," Opt. Lett. 32, 3002-3004 (2007)

Sort:  Year  |  Journal  |  Reset  


  1. R. A. Kruger, K. K. Kopecky, A. M. Aisen, D. R. Reinecke, G. A. Kruger, and W. L. Kiser, Radiology 211, 275 (1999). [PubMed]
  2. R. O. Esenaliev, A. A. Karabutov, and A. A. Oraevsky, IEEE J. Sel. Top. Quantum Electron. 5, 981 (1999). [CrossRef]
  3. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, Nat. Biotechnol. 21, 803 (2003). [CrossRef] [PubMed]
  4. H. F. Zhang, K. Maslov, G. Stoica, and L.-H. Wang, Nat. Biotechnol. 24, 848 (2006). [CrossRef] [PubMed]
  5. X. Wang, D. L. Chamberland, P. L. Carson, J. B. Fowlkes, R. O. Bude, and D. A. Jamadar, Med. Phys. 33, 2691 (2006). [CrossRef] [PubMed]
  6. M. Xu and L.-H. Wang, IEEE Trans. Med. Imaging 21, 814 (2002). [CrossRef] [PubMed]
  7. M. A. Anastasio, J. Zhang, X. Pan, Y. Zou, G. Ku, and L. V. Wang, IEEE Trans. Med. Imaging 24, 199 (2005). [CrossRef] [PubMed]
  8. P. R. Hoskins, T. Anderson, M. Sharp, S. Meagher, T. McGillivray, and W. N. McDicken, in 2004 IEEE International Ultrasonics Symposium Proceedings (IEEE, 2004), pp. 752-755. [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited