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Optics Letters

Optics Letters


  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 21 — Nov. 1, 2007
  • pp: 3092–3094

Enhanced surface plasmon resonance imaging detection of DNA hybridization on periodic gold nanoposts

L. Malic, B. Cui, T. Veres, and M. Tabrizian  »View Author Affiliations

Optics Letters, Vol. 32, Issue 21, pp. 3092-3094 (2007)

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We explore periodic gold nanoposts as substrates for the enhanced surface plasmon resonance imaging (SPRi) detection of DNA hybridization. Rigorous coupled-wave analysis was used to model and design the nanopost-based SPRi biosensor. Arrayed gold nanoposts on gold-coated glass substrate, with various widths and periodicity, were fabricated using electron-beam lithography and characterized with scanning electron and atomic force microscopy. A scanning-angle SPRi apparatus was used to conduct the kinetic analysis of DNA hybridization on nanopost-based sensor surface and assess the corresponding SPR signal amplification. Experimental results showed that both the nanostructure size and period influenced the SPR signal enhancement; the optimized 30 nm height, 50 nm size, and 110 nm period nanoposts provided a fivefold SPR signal amplification compared with the plain 50 nm thick gold film used as control.

© 2007 Optical Society of America

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(130.6010) Integrated optics : Sensors
(240.5420) Optics at surfaces : Polaritons
(240.6680) Optics at surfaces : Surface plasmons
(310.6860) Thin films : Thin films, optical properties

ToC Category:
Optics at Surfaces

Original Manuscript: June 25, 2007
Revised Manuscript: August 22, 2007
Manuscript Accepted: August 29, 2007
Published: October 18, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

L. Malic, B. Cui, T. Veres, and M. Tabrizian, "Enhanced surface plasmon resonance imaging detection of DNA hybridization on periodic gold nanoposts," Opt. Lett. 32, 3092-3094 (2007)

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