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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 22 — Nov. 15, 2007
  • pp: 3239–3241

In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror

Woonggyu Jung, Daniel T. McCormick, Yeh-Chan Ahn, Ali Sepehr, Matt Brenner, Brian Wong, Norman C. Tien, and Zhongping Chen  »View Author Affiliations


Optics Letters, Vol. 32, Issue 22, pp. 3239-3241 (2007)
http://dx.doi.org/10.1364/OL.32.003239


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Abstract

A biopsy is a well-known medical test used to evaluate tissue abnormality. Biopsy specimens are invasively taken from part of a lesion and visualized by microscope after chemical treatment. However, diagnosis by means of biopsy is not only variable due to depth and location of specimen but may also damage the specimen. In addition, only a limited number of specimens can be obtained, thus, the entire tissue morphology cannot be observed. We introduce a three-dimensional (3-D) endoscopic optical biopsy via optical coherence tomography employing a dual-axis microelectromechanical system scanning mirror. Since this technique provides high-resolution, noninvasive, direct, and multiple visualization of tissue, it could function as a clinical biopsy with advanced performance. The device was integrated with a conventional endoscope and utilized to generate in vivo 3-D clinical images in humans and animals.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 8, 2007
Revised Manuscript: September 26, 2007
Manuscript Accepted: September 26, 2007
Published: November 1, 2007

Virtual Issues
Vol. 2, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Woonggyu Jung, Daniel T. McCormick, Yeh-Chan Ahn, Ali Sepehr, Matt Brenner, Brian Wong, Norman C. Tien, and Zhongping Chen, "In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror," Opt. Lett. 32, 3239-3241 (2007)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-22-3239

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