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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Anthony J. Campillo
  • Vol. 32, Iss. 9 — May. 1, 2007
  • pp: 1102–1104

Large area confocal microscopy

D. Yelin, C. Boudoux, B. E. Bouma, and G. J. Tearney  »View Author Affiliations


Optics Letters, Vol. 32, Issue 9, pp. 1102-1104 (2007)
http://dx.doi.org/10.1364/OL.32.001102


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Abstract

Imaging large tissue areas with microscopic resolution in vivo may offer an alternative to random excisional biopsy. We present an approach for performing confocal imaging of large tissue surface areas using spectrally encoded confocal microscopy (SECM). We demonstrate a single-optical-fiber SECM apparatus, designed for imaging luminal organs, that is capable of imaging with a transverse resolution of 2.1 μ m over a subsurface area of 16 cm 2 in less than 1 min . Due to the unique probe configuration and scanning geometery, the speed and resolution of this new imaging technology are sufficient for comprehensively imaging large tissues areas at a microscopic scale in times that are appropriate for clinical use.

© 2007 Optical Society of America

OCIS Codes
(110.0180) Imaging systems : Microscopy
(170.1790) Medical optics and biotechnology : Confocal microscopy
(170.2150) Medical optics and biotechnology : Endoscopic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 8, 2006
Revised Manuscript: January 16, 2007
Manuscript Accepted: February 1, 2007
Published: April 3, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
D. Yelin, C. Boudoux, B. E. Bouma, and G. J. Tearney, "Large area confocal microscopy," Opt. Lett. 32, 1102-1104 (2007)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-32-9-1102

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