Label-free biosensor by protein grating coupler on planar optical waveguides
Optics Letters, Vol. 33, Issue 15, pp. 1735-1737 (2008)
http://dx.doi.org/10.1364/OL.33.001735
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Abstract
We report a diffraction-based, label-free biosensor on the surface of a planar optical waveguide. By selectively immobilizing proteins on an optical waveguide, the proteins can form the ridge/valley of a latent image optical grating. Binding events with patterned surface proteins dynamically increase grating height and cause an increase in light coupling out of the waveguide. We demonstrate the efficacy of this strategy for protein detection and present the design and fabrication of a device.
© 2008 Optical Society of America
OCIS Codes
(130.3120) Integrated optics : Integrated optics devices
(230.1950) Optical devices : Diffraction gratings
(230.7390) Optical devices : Waveguides, planar
(280.1415) Remote sensing and sensors : Biological sensing and sensors
ToC Category:
Optical Devices
History
Original Manuscript: February 19, 2008
Revised Manuscript: June 5, 2008
Manuscript Accepted: June 16, 2008
Published: July 29, 2008
Virtual Issues
Vol. 3, Iss. 9 Virtual Journal for Biomedical Optics
Citation
Zhian Lai, Yuli Wang, Nancy Allbritton, G.-P. Li, and Mark Bachman, "Label-free biosensor by protein grating coupler on planar optical waveguides," Opt. Lett. 33, 1735-1737 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-15-1735
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