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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 33, Iss. 19 — Oct. 1, 2008
  • pp: 2263–2265

Visualizing of skin chromophore concentrations by use of RGB images

Izumi Nishidate, Kiyohiro Sasaoka, Testuya Yuasa, Kyuichi Niizeki, Takaaki Maeda, and Yoshihisa Aizu  »View Author Affiliations

Optics Letters, Vol. 33, Issue 19, pp. 2263-2265 (2008)

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A method is proposed for visualizing simply the concentrations of melanin, oxygenated blood, and deoxygenated blood in skin tissue using digital RGB images. The total blood concentration and oxygen saturation can also be reconstructed. Monte Carlo simulation of light transport specifies a relation between the chromophore concentrations and Commission Internationale de l'Éclairage X Y Z , which are compatible with the common RGB working space. Experiments with a tissuelike agar gel phantom demonstrated the possibility of the method. In vivo imaging of a human hand during forearm occlusion demonstrated the ability of the method to evaluate hemodynamics of skin tissue.

© 2008 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: June 13, 2008
Revised Manuscript: August 11, 2008
Manuscript Accepted: August 28, 2008
Published: September 30, 2008

Virtual Issues
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Izumi Nishidate, Kiyohiro Sasaoka, Testuya Yuasa, Kyuichi Niizeki, Takaaki Maeda, and Yoshihisa Aizu, "Visualizing of skin chromophore concentrations by use of RGB images," Opt. Lett. 33, 2263-2265 (2008)

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  1. V. P. Wallace, D. C. Crawford, P. S. Mortimer, R. J. Ott, and J. C. Bamber, Mead Johnson Symp. Perinat. Dev. Med. 45, 735 (2000).
  2. I. Nishidate, Y. Aizu, and H. Mishina, J. Biomed. Opt. 9, 700 (2004). [CrossRef] [PubMed]
  3. P. R. Bargo, S. A. Prahl, T. T. Goodell, R. A. Sleven, G. Koval, G. Blair, and S. L. Jacques, J. Biomed. Opt. 10, 034018 (2005). [CrossRef] [PubMed]
  4. A. K. Dunn, A. Devor, H. Bolay, M. L. Andermann, M. A. Moskowitz, A. M. Dale, and D. A. Boas, Opt. Lett. 28, 28 (2003). [CrossRef] [PubMed]
  5. M. G. Sowa, J. R. Payette, M. D. Hewko, and H. H. Mantsch, J. Biomed. Opt. 4, 474 (1999). [CrossRef]
  6. M. J. Leahy, J. O'Doherty, G. E. Nilsson, J. Henricson, C. Anderson, and F. Sjoberg, SPIE Newsroom 10.1117/2.1200701.0504 (2007), http://spie.org/x18138.xml.
  7. D. Nakao, N. Tsumura, and Y. Miyake, Med. Imaging Technol. 20, 123 (2002).
  8. K. N. Plataniotis and A. N. Venetsanopoulos, Color Imaging Processing and Applications (Springer, 2000).
  9. L.-H. Wang, S. L. Jacques, and L.-Q. Zheng, Comput. Methods Programs Biomed. 47, 131 (1995). [CrossRef] [PubMed]
  10. S. L. Jacques, R. D. Glickman, and J. A. Schwartz, Proc. SPIE 2681, 468 (1996). [CrossRef]
  11. I. Nishidate, T. Maeda, Y. Aizu, and K. Niizeki, J. Biomed. Opt. 12, 054006 (2007). [CrossRef] [PubMed]
  12. Y. Higashi, S. Sasaki, K. Nakagawa, T. Ueda, A. Yoshimizu, S. Kurisu, H. Matsuura, G. Kajiyama, and T. Oshima, J. Am. Coll. Cardiol. 35, 284 (2002). [CrossRef]

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