Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging
Optics Letters, Vol. 33, Issue 21, pp. 2494-2496 (2008)
http://dx.doi.org/10.1364/OL.33.002494
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Abstract
We propose a fluorescent x-ray computed tomography method using an array of detectors with an incident sheet beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution. In this study, we prove the feasibility of this concept and investigate its imaging properties, including spatial and contrast resolutions and quantitativeness, by imaging an acrylic phantom and a normal mouse brain using a preliminary imaging system with monochromatic synchrotron x rays.
© 2008 Optical Society of America
OCIS Codes
(110.7440) Imaging systems : X-ray imaging
(170.6960) Medical optics and biotechnology : Tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: June 24, 2008
Revised Manuscript: August 20, 2008
Manuscript Accepted: August 22, 2008
Published: October 24, 2008
Virtual Issues
Vol. 4, Iss. 1 Virtual Journal for Biomedical Optics
Citation
Qingkai Huo, Tetsuya Yuasa, Takao Akatsuka, Tohoru Takeda, Jin Wu, Thet-Thet-Lwin, Kazuyuki Hyodo, and F. Avraham Dilmanian, "Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging," Opt. Lett. 33, 2494-2496 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-21-2494
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