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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 33, Iss. 4 — Feb. 15, 2008
  • pp: 342–344

Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina

You-Bo Zhao and Xin-Cheng Yao  »View Author Affiliations

Optics Letters, Vol. 33, Issue 4, pp. 342-344 (2008)

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We demonstrated near-infrared light imaging of stimulus-modulated physiological activities in an isolated frog retina using transient intrinsic optical responses (TIORs). While low-strength visible-light stimuli evoked TIORs with positive polarity, strengthened stimuli elicited additional negative TIORs. Our experimental study and physiological analysis suggest that the negative TIORs are associated with photoreceptor response, and the positive TIORs result primarily from dynamic changes of postphotoreceptor response during retinal activation. In coordination with the sophisticated design of visible-light stimulation protocols, optical imaging of TIORs promises an important application for noninvasive assessment of retinal photoreceptor and inner neurons.

© 2008 Optical Society of America

OCIS Codes
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(170.5755) Medical optics and biotechnology : Retina scanning

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 30, 2007
Revised Manuscript: January 3, 2008
Manuscript Accepted: January 10, 2008
Published: February 11, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

You-Bo Zhao and Xin-Cheng Yao, "Intrinsic optical imaging of stimulus-modulated physiological responses in amphibian retina," Opt. Lett. 33, 342-344 (2008)

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