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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 33, Iss. 6 — Mar. 15, 2008
  • pp: 624–626

Scattering differentiates Alzheimer disease in vitro

Eugene B. Hanlon, Lev T. Perelman, Eduard I. Vitkin, Frank A. Greco, Ann C. McKee, and Neil W. Kowall  »View Author Affiliations

Optics Letters, Vol. 33, Issue 6, pp. 624-626 (2008)

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The molecular bases of Alzheimer disease and related neurodegenerative disorders are becoming better understood, but the means for definitive diagnosis and monitoring in vivo remain lacking. Near-infrared optical spectroscopy offers a potential solution. We acquired transmission and reflectance spectra of thin brain tissue slabs, from which we calculated wavelength-dependent absorption and reduced scattering coefficients from 470 1000 nm . The reduced scattering coefficients in the near infrared clearly differentiated Alzheimer from control specimens. Diffuse reflectance spectra of gross brain tissue in vitro confirmed this observation. These results suggest a means for diagnosing and monitoring Alzheimer disease in vivo, using near-infrared optical spectroscopy.

© 2008 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(290.5825) Scattering : Scattering theory

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 20, 2007
Revised Manuscript: February 6, 2008
Manuscript Accepted: February 8, 2008
Published: March 14, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Eugene B. Hanlon, Lev T. Perelman, Eduard I. Vitkin, Frank A. Greco, Ann C. McKee, and Neil W. Kowall, "Scattering differentiates Alzheimer disease in vitro," Opt. Lett. 33, 624-626 (2008)

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