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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 33, Iss. 7 — Apr. 1, 2008
  • pp: 708–710

Label-free optical biosensing with slot-waveguides

Carlos A. Barrios, María José Bañuls, Victoria González-Pedro, Kristinn B. Gylfason, Benito Sánchez, Amadeu Griol, A. Maquieira, H. Sohlström, M. Holgado, and R. Casquel  »View Author Affiliations

Optics Letters, Vol. 33, Issue 7, pp. 708-710 (2008)

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We demonstrate label-free molecule detection by using an integrated biosensor based on a Si 3 N 4 SiO 2 slot-waveguide microring resonator. Bovine serum albumin (BSA) and anti-BSA molecular binding events on the sensor surface are monitored through the measurement of resonant wavelength shifts with varying biomolecule concentrations. The biosensor exhibited sensitivities of 1.8 and 3.2 nm ( ng mm 2 ) for the detection of anti-BSA and BSA, respectively. The estimated detection limits are 28 and 16 pg mm 2 for anti-BSA and BSA, respectively, limited by wavelength resolution.

© 2008 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(230.5750) Optical devices : Resonators

ToC Category:
Optical Devices

Original Manuscript: November 8, 2007
Revised Manuscript: February 26, 2008
Manuscript Accepted: February 26, 2008
Published: March 28, 2008

Virtual Issues
Vol. 3, Iss. 5 Virtual Journal for Biomedical Optics

Carlos A. Barrios, María José Bañuls, Victoria González-Pedro, Kristinn B. Gylfason, Benito Sánchez, Amadeu Griol, A. Maquieira, H. Sohlström, M. Holgado, and R. Casquel, "Label-free optical biosensing with slot-waveguides," Opt. Lett. 33, 708-710 (2008)

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