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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 33, Iss. 7 — Apr. 1, 2008
  • pp: 711–713

Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers

Michael A. Short, Stephen Lam, Annette McWilliams, Jianhua Zhao, Harvey Lui, and Haishan Zeng  »View Author Affiliations

Optics Letters, Vol. 33, Issue 7, pp. 711-713 (2008)

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A near-infrared Raman system was developed to collect real-time in vivo human lung spectra. The excitation light and the emission were guided to and from the tissue surface by a reusable fiber catheter passed down the instrument channel of a bronchoscope. Two-stage filtering was used to reduce laser noise, fluorescence, and Raman emissions from the fibers. A second fiber bundle guided the emission to a spectrometer where the fibers, in a round packing geometry, were spread out to form a parabolic arc that improved the signal-to-noise ratio 20-fold, facilitating real-time spectral measurements. Preliminary clinical tests show that clear and reliable Raman spectra can be obtained.

© 2008 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 21, 2007
Revised Manuscript: February 7, 2008
Manuscript Accepted: February 20, 2008
Published: March 28, 2008

Virtual Issues
Vol. 3, Iss. 5 Virtual Journal for Biomedical Optics

Michael A. Short, Stephen Lam, Annette McWilliams, Jianhua Zhao, Harvey Lui, and Haishan Zeng, "Development and preliminary results of an endoscopic Raman probe for potential in vivo diagnosis of lung cancers," Opt. Lett. 33, 711-713 (2008)

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