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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 33, Iss. 7 — Apr. 1, 2008
  • pp: 714–716

Integrated Raman- and angular-scattering microscopy

Zachary J. Smith and Andrew J. Berger  »View Author Affiliations


Optics Letters, Vol. 33, Issue 7, pp. 714-716 (2008)
http://dx.doi.org/10.1364/OL.33.000714


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Abstract

A microscopy system has been constructed that is capable of simultaneously acquiring both traditional Raman spectra as well as angle-resolved elastic-scattering patterns using a single focused laser spot less than 10 μ m wide. The elastic-scattering signal was analyzed by generalized Lorenz–Mie theory, representing what we believe to be the first experimental validation of the theory’s prediction of angular backscatter from single spheres. The microscope system exhibits 3 nm precision in predicting sphere diameters, while simultaneously yielding high-quality Raman signals. Applications to single cell analysis are envisioned.

© 2008 Optical Society of America

OCIS Codes
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(290.4020) Scattering : Mie theory

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: December 20, 2007
Revised Manuscript: February 22, 2008
Manuscript Accepted: February 27, 2008
Published: March 28, 2008

Virtual Issues
Vol. 3, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Zachary J. Smith and Andrew J. Berger, "Integrated Raman- and angular-scattering microscopy," Opt. Lett. 33, 714-716 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-7-714


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