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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 33, Iss. 8 — Apr. 15, 2008
  • pp: 842–844

High-speed wave-mixing laser Doppler imaging in vivo

M. Atlan, M. Gross, T. Vitalis, A. Rancillac, J. Rossier, and A. C. Boccara  »View Author Affiliations

Optics Letters, Vol. 33, Issue 8, pp. 842-844 (2008)

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An interferometric method for parallel optical spectroscopy in the kilohertz range is reported, as well as its experimental validation in the context of high-speed laser Doppler imaging in vivo. The interferometric approach enables imaging in the low light conditions of a 2 kHz frame rate recording with a complementary metal-oxide semiconductor camera. Observation of mice craniums with near-infrared ( λ = 785 nm ) laser light in reflection configuration is reported. Doppler spectral images allegedly sensitive to blood flow are sequentially measured at several optical frequency detunings, to shift the spectral range of analysis in the radio-frequency spectrum.

© 2008 Optical Society of America

OCIS Codes
(040.2840) Detectors : Heterodyne
(090.2880) Holography : Holographic interferometry
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 3, 2008
Revised Manuscript: March 2, 2008
Manuscript Accepted: March 4, 2008
Published: April 14, 2008

Virtual Issues
Vol. 3, Iss. 5 Virtual Journal for Biomedical Optics

M. Atlan, M. Gross, T. Vitalis, A. Rancillac, J. Rossier, and A. C. Boccara, "High-speed wave-mixing laser Doppler imaging in vivo," Opt. Lett. 33, 842-844 (2008)

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