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  • Vol. 33, Iss. 9 — May. 1, 2008
  • pp: 1035–1037

Estimating the depth and lifetime of a fluorescent inclusion in a turbid medium using a simple time-domain optical method

Sung-Ho Han and David J. Hall  »View Author Affiliations


Optics Letters, Vol. 33, Issue 9, pp. 1035-1037 (2008)
http://dx.doi.org/10.1364/OL.33.001035


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Abstract

A simple time-domain optical method for estimating the depth ( d ) and lifetime ( τ ) of fluorescent inclusions in a turbid medium is described. We demonstrate the method for depth and lifetime estimation of a fluorescent inclusion directly by fitting a monoexponential decay ( τ eff ) of the temporal position of the temporal point-spread function and the measurement of its maximum temporal position ( t max ) . Since both of these measurements are intensity independent, this method provides a robust and efficient approach. This method is validated with experimental data.

© 2008 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.7050) Medical optics and biotechnology : Turbid media
(300.6280) Spectroscopy : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 4, 2008
Revised Manuscript: March 11, 2008
Manuscript Accepted: March 14, 2008
Published: April 30, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Sung-Ho Han and David J. Hall, "Estimating the depth and lifetime of a fluorescent inclusion in a turbid medium using a simple time-domain optical method," Opt. Lett. 33, 1035-1037 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-9-1035


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References

  1. V. Ntziachristos, J. Ripoll, L. V. Wang, and R. Weissleder, Nat. Biotechnol. 23, 313 (2005). [CrossRef] [PubMed]
  2. R. Weissleder and V. Ntziachrostos, Nat. Med. 9, 123 (2003). [CrossRef] [PubMed]
  3. E. E. Graves, J. Ripoll, R. Weissleder, and V. Ntziachristos, Med. Phys. 30, 901 (2003). [CrossRef] [PubMed]
  4. J. Virostko, A. C. Powers, and E. D. Jansen, Appl. Opt. 46, 2540 (2007). [CrossRef] [PubMed]
  5. D. Hall, G. Ma, F. Lesage, and Y. Wang, Opt. Lett. 29, 2258 (2004). [CrossRef] [PubMed]
  6. M. A. O'Leary, D. A. Boas, X. D. Li, B. Chance, and A. G. Yodh, Opt. Lett. 21, 158 (1996). [CrossRef] [PubMed]
  7. X. D. Li, M. A. O'Leary, D. A. Boas, B. Chance, and A. G. Yodh, Appl. Opt. 35, 3746 (1996). [CrossRef] [PubMed]
  8. D. J. Hawrysz and E. M. Sevick-Muraca, Neoplasia 2, 388 (2000). [CrossRef]
  9. V. Ntziachristos and R. Weissleder, Opt. Lett. 26, 893 (2001). [CrossRef]
  10. A. T. N. Kumar, J. Skoch, B. J. Bacskai, D. A. Boas, and A. K. Dunn, Opt. Lett. 30, 3347 (2005). [CrossRef]
  11. A. T. N. Kumar, S. B. Raymond, G. Boveran, D. A. Boas, and B. J. Bacskai, Opt. Express 14, 12255 (2006). [CrossRef] [PubMed]
  12. A. Laidevant, A. Da Silva, M. Berger, J. Boutet, J.-M. Dinten, and A. C. Boccara, Appl. Opt. 46, 2131 (2007). [CrossRef] [PubMed]
  13. S. Chandrasekhar, Rev. Mod. Phys. 15, 1 (1943). [CrossRef]
  14. M. S. Patterson, B. Chance, and B. C. Wilson, Appl. Opt. 28, 2331 (1989). [CrossRef] [PubMed]
  15. H. J. van Staveren, C. J. M. Moes, J. van Marle, S. A. Prahl, and M. J. C. van Gemert, Appl. Opt. 30, 4507 (1991). [CrossRef] [PubMed]
  16. D. J. Hall and S.-H. Han, Proc. SPIE 6430, 6430T (2007).

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