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  • Vol. 33, Iss. 9 — May. 1, 2008
  • pp: 929–931

Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries

Konstantin Maslov, Hao F. Zhang, Song Hu, and Lihong V. Wang  »View Author Affiliations


Optics Letters, Vol. 33, Issue 9, pp. 929-931 (2008)
http://dx.doi.org/10.1364/OL.33.000929


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Abstract

Capillaries, the smallest blood vessels, are the distal end of the vasculature where oxygen and nutrients are exchanged between blood and tissue. Hence, noninvasive imaging of capillaries and function in vivo has long been desired as a window to studying fundamental physiology, such as neurovascular coupling. Existing imaging modalities cannot provide the required sensitivity and spatial resolution. We present in vivo imaging of the microvasculature including single capillaries in mice using optical-resolution photoacoustic microscopy (OR-PAM) developed in our laboratory. OR-PAM provides a lateral resolution of 5 μ m and an imaging depth > 0.7 mm .

© 2008 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 30, 2008
Manuscript Accepted: March 2, 2008
Published: April 23, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Konstantin Maslov, Hao F. Zhang, Song Hu, and Lihong V. Wang, "Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries," Opt. Lett. 33, 929-931 (2008)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-33-9-929


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References

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  2. A. A. Oraevsky and A. A. Karabutov, “Optoacoustic tomography,” in Biomedical Photonics Handbook, T.Vo-Dinh, ed. (CRC Press, 2003), Vol. PM125, Chap. 34.
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