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Optics Letters

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  • Editor: Alan E. Willner
  • Vol. 34, Iss. 10 — May. 15, 2009
  • pp: 1525–1527

Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation

Arjen Amelink, Theo Christiaanse, and Henricus J. C. M. Sterenborg  »View Author Affiliations


Optics Letters, Vol. 34, Issue 10, pp. 1525-1527 (2009)
http://dx.doi.org/10.1364/OL.34.001525


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Abstract

Fiber-optic reflectance measurements were performed on scattering phantoms containing red blood cells. The oxygen pressure in the phantom was decreased by nitrogen gas bubbling, while carefully controlling and monitoring the temperature ( 37 ° C ) and pH (7.4). The blood oxygen saturation ( S O 2 ) was extracted from the optical spectroscopic measurements by fitting the spectra over the wavelength range of 350 850     nm to a model that includes the effects of pigment packaging. The effect of using different oxy- and deoxyhemoglobin extinction spectra on the quality and accuracy of the fits is analyzed. The optically extracted S O 2 is compared with the standard oxygen dissociation curve (ODC). Depending on the choice of hemoglobin extinction spectra the absolute deviation between the ODC and the optically extracted S O 2 is less than 2.5% over the measured range of saturations (4%–99%).

© 2009 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: January 23, 2009
Revised Manuscript: March 24, 2009
Manuscript Accepted: April 3, 2009
Published: May 8, 2009

Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Arjen Amelink, Theo Christiaanse, and Henricus J. C. M. Sterenborg, "Effect of hemoglobin extinction spectra on optical spectroscopic measurements of blood oxygen saturation," Opt. Lett. 34, 1525-1527 (2009)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-34-10-1525


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