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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 12 — Jun. 15, 2009
  • pp: 1816–1818

Resonant four-wave mixing of gold nanoparticles for three-dimensional cell microscopy

Francesco Masia, Wolfgang Langbein, Peter Watson, and Paola Borri  »View Author Affiliations

Optics Letters, Vol. 34, Issue 12, pp. 1816-1818 (2009)

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By detecting the transient four-wave mixing from gold nanoparticles in resonance with their surface plasmon, we demonstrate a multiphoton imaging modality suited for cell microscopy. Four-wave mixing is measured free from background using a three-beam excitation geometry and heterodyne detection. We achieve a spatial resolution of 140 nm in-plane and 470 nm in the axial direction, surpassing the one-photon diffraction limit. With this technique, high-contrast photostable imaging of Golgi structures is demonstrated in HepG2 cells labeled with gold nanoparticles of 10 nm and 5 nm diameter.

© 2009 Optical Society of America

OCIS Codes
(180.6900) Microscopy : Three-dimensional microscopy
(190.4380) Nonlinear optics : Nonlinear optics, four-wave mixing

ToC Category:
Nonlinear Optics

Original Manuscript: April 8, 2009
Manuscript Accepted: May 6, 2009
Published: June 8, 2009

Virtual Issues
Vol. 4, Iss. 8 Virtual Journal for Biomedical Optics

Francesco Masia, Wolfgang Langbein, Peter Watson, and Paola Borri, "Resonant four-wave mixing of gold nanoparticles for three-dimensional cell microscopy," Opt. Lett. 34, 1816-1818 (2009)

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