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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 34, Iss. 16 — Aug. 15, 2009
  • pp: 2477–2479

Hyperspectral excitation-resolved fluorescence tomography of quantum dots

Alexander D. Klose  »View Author Affiliations


Optics Letters, Vol. 34, Issue 16, pp. 2477-2479 (2009)
http://dx.doi.org/10.1364/OL.34.002477


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Abstract

The proposed method exploits the spectral properties of tissue hemoglobin for the purpose of 3D image reconstruction of quantum dot reporter probes inside scattering tissue. It advances fluorescence tomography in such way that only a single light source with tunable wavelength selection is required for fluorescence stimulation and image reconstruction. Numerical results suggest that current planar surface imaging technology could easily be retrofitted for performing fluorescence tomography without the use of elaborate source–detector multiplexing.

© 2009 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5280) Medical optics and biotechnology : Photon migration
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 21, 2009
Revised Manuscript: June 30, 2009
Manuscript Accepted: July 6, 2009
Published: August 12, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Alexander D. Klose, "Hyperspectral excitation-resolved fluorescence tomography of quantum dots," Opt. Lett. 34, 2477-2479 (2009)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-34-16-2477


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References

  1. J. Rao, A. Dragulescu-Andrasi, and H. Yao, Curr. Opin. Biotechnol. 18, 17 (2007). [CrossRef] [PubMed]
  2. V. Ntziachristos, Annu. Rev. Biomed. Eng. 8, 1 (2006). [CrossRef] [PubMed]
  3. S. A. Prahl, http://omlc.ogi.edu/spectra/hemoglobin/index.html.
  4. S. Lin, X. Xie, M. R. Patel, Y.-H. Yang, Z. Li, F. Cao, O. Gheysens, Y. Zhang, S. S. Gambhir, J. H. Rao, and J. C. Wu, BMC Biotechnol. 7, 67 (2007). [CrossRef] [PubMed]
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  6. A. D. Klose and E. W. Larsen, J. Comp. Physics 220, 441 (2006). [CrossRef]

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