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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 2 — Jan. 15, 2009
  • pp: 145–147

Three-dimensional adaptive microscopy using embedded liquid lens

Supraja Murali, Kevin P. Thompson, and Jannick P. Rolland  »View Author Affiliations

Optics Letters, Vol. 34, Issue 2, pp. 145-147 (2009)

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We report on the compact optical design of a high-resolution 3D scanning microscope with adaptive optics capability for refocusing with no moving parts designed for clinical research. The optical aberrations arising from refocusing are compensated for as part of the multiconfiguration optical design process. The lateral scanning is provided by a scanning mirror, and the depth scan is provided by an adaptive liquid lens embedded within the microscope as an integrated component of a custom optical design. The microscope achieves a performance of 250 lp mm —a tenfold increase in performance over a liquid lens used as a stand-alone optical element. Results show that the optical design provides invariant modular transfer function over a 2 mm × 2 mm × 2 mm imaging volume, fully compensating (i.e., diffraction limited) for dynamic aberrations contributed by the scanning, the variation in the shape of the liquid lens, and the change in spherical aberration with depth in a slab of average index of refraction of skin. This design can find applications in biomedical imaging, white light interferometry for surface roughness measurements, and other 3D imaging systems.

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(220.3620) Optical design and fabrication : Lens system design
(220.1080) Optical design and fabrication : Active or adaptive optics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 27, 2008
Manuscript Accepted: November 10, 2008
Published: January 13, 2009

Virtual Issues
Vol. 4, Iss. 3 Virtual Journal for Biomedical Optics

Supraja Murali, Kevin P. Thompson, and Jannick P. Rolland, "Three-dimensional adaptive microscopy using embedded liquid lens," Opt. Lett. 34, 145-147 (2009)

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