OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 20 — Oct. 15, 2009
  • pp: 3086–3088

Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

Vivek J. Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, and David A. Boas  »View Author Affiliations

Optics Letters, Vol. 34, Issue 20, pp. 3086-3088 (2009)

View Full Text Article

Enhanced HTML    Acrobat PDF (513 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

© 2009 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5380) Medical optics and biotechnology : Physiology

ToC Category:
Imaging Systems

Original Manuscript: September 3, 2009
Revised Manuscript: September 3, 2009
Manuscript Accepted: September 3, 2009
Published: October 6, 2009

Virtual Issues
Vol. 4, Iss. 12 Virtual Journal for Biomedical Optics

Vivek J. Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, and David A. Boas, "Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography," Opt. Lett. 34, 3086-3088 (2009)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. A. Grinvald, R. D. Frostig, E. Lieke, and R. Hildesheim, Physiol. Rev. 68, 1285 (1988). [PubMed]
  2. A. Villringer and B. Chance, Trends Neurosci. 20, 435 (1997). [CrossRef] [PubMed]
  3. D. Y. Tso, R. D. Frostig, E. E. Lieke, and A. Grinvald, Science 249, 417 (1990). [CrossRef]
  4. B. M. Ances, J. H. Greenberg, and J. A. Detre, Neuroimage 10, 716 (1999). [CrossRef] [PubMed]
  5. A. F. Fercher and J. D. Briers, Opt. Commun. 37, 326 (1981). [CrossRef]
  6. D. Kleinfeld, P. P. Mitra, F. Helmchen, and W. Denk, Proc. Natl. Acad. Sci. USA 95, 15741 (1998). [CrossRef] [PubMed]
  7. R. U. Maheswari, H. Takaoka, H. Kadono, R. Homma, and M. Tanifuji, J. Neurosci. Methods 124, 83 (2003). [CrossRef] [PubMed]
  8. Y. Chen, A. D. Aguirre, L. Ruvinskaya, A. Devor, D. A. Boas, and J. G. Fujimoto, J. Neurosci. Methods 178, 162 (2008). [CrossRef]
  9. R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, Opt. Express 15, 4083 (2007). [CrossRef] [PubMed]
  10. A. Devor, P. Tian, N. Nishimura, I. C. Teng, E. M. Hillman, S. N. Narayanan, I. Ulbert, D. A. Boas, D. Kleinfeld, and A. M. Dale, J. Neurosci. 27, 4452 (2007). [CrossRef] [PubMed]
  11. H. Ren, T. Sun, D. J. MacDonald, M. J. Cobb, and X. Li, Opt. Lett. 31, 927 (2006). [CrossRef] [PubMed]
  12. C. Kasai, K. Namekawa, A. Koyano, and R. Omoto, IEEE Trans. Sonics Ultrason. 32, 458 (1985).
  13. D. J. Faber, F. J. van der Meer, and M. C. G. Aalders, Opt. Express 12, 4353 (2004). [CrossRef] [PubMed]
  14. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, Opt. Express 11, 889 (2003). [CrossRef] [PubMed]
  15. V. J. Srinivasan, M. Wojtkowski, J. G. Fujimoto, and J. S. Duker, Opt. Lett. 31, 2308 (2006). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited