OSA's Digital Library

Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 34, Iss. 3 — Feb. 1, 2009
  • pp: 289–291

Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging

Melissa C. Skala, Andrew Fontanella, Hansford Hendargo, Mark W. Dewhirst, and Joseph A. Izatt  »View Author Affiliations


Optics Letters, Vol. 34, Issue 3, pp. 289-291 (2009)
http://dx.doi.org/10.1364/OL.34.000289


View Full Text Article

Enhanced HTML    Acrobat PDF (355 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We have combined hyperspectral imaging with spectral domain optical coherence tomography (SDOCT) to noninvasively image changes in hemoglobin saturation, blood flow, microvessel morphology, and sheer rate on the vessel wall with tumor growth. Changes in these hemodynamic variables were measured over 24 h in dorsal skin fold window chamber tumors. There was a strong correlation between volumetric flow and hemoglobin saturation ( ρ = 0.89 , p = 9 × 10 6 , N = 15 ) and a moderate correlation between shear rate on the vessel wall and hemoglobin saturation ( ρ = 0.56 , p = 0.03 , N = 15 ).

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 27, 2008
Manuscript Accepted: November 27, 2008
Published: January 26, 2009

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Melissa C. Skala, Andrew Fontanella, Hansford Hendargo, Mark W. Dewhirst, and Joseph A. Izatt, "Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging," Opt. Lett. 34, 289-291 (2009)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-34-3-289

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited