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Optics Letters

Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 34, Iss. 6 — Mar. 15, 2009
  • pp: 758–760

Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy

Zhiwei Huang, Seng Khoon Teh, Wei Zheng, Jianhua Mo, Kan Lin, Xiaozhuo Shao, Khek Yu Ho, Ming Teh, and Khay Guan Yeoh  »View Author Affiliations


Optics Letters, Vol. 34, Issue 6, pp. 758-760 (2009)
http://dx.doi.org/10.1364/OL.34.000758


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Abstract

We report an integrated Raman spectroscopy and trimodal (white-light reflectance, autofluorescence, and narrow-band) imaging techniques for real-time in vivo tissue Raman measurements at endoscopy. A special 1.8 mm endoscopic Raman probe with filtering modules is developed, permitting effective elimination of interference of fluorescence background and silica Raman in fibers while maximizing tissue Raman collections. We demonstrate that high-quality in vivo Raman spectra of upper gastrointestinal tract can be acquired within 1 s or subseconds under the guidance of wide-field endoscopic imaging modalities, greatly facilitating the adoption of Raman spectroscopy into clinical research and practice during routine endoscopic inspections.

© 2009 Optical Society of America

OCIS Codes
(170.1610) Medical optics and biotechnology : Clinical applications
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 18, 2008
Revised Manuscript: January 20, 2009
Manuscript Accepted: February 2, 2009
Published: March 6, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Zhiwei Huang, Seng Khoon Teh, Wei Zheng, Jianhua Mo, Kan Lin, Xiaozhuo Shao, Khek Yu Ho, Ming Teh, and Khay Guan Yeoh, "Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy," Opt. Lett. 34, 758-760 (2009)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-34-6-758

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