OSA's Digital Library

Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 7 — Apr. 1, 2009
  • pp: 926–928

Spatially offset Raman spectroscopy of layered soft tissues

Matthew D. Keller, Shovan K. Majumder, and Anita Mahadevan-Jansen  »View Author Affiliations

Optics Letters, Vol. 34, Issue 7, pp. 926-928 (2009)

View Full Text Article

Enhanced HTML    Acrobat PDF (249 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Raman spectroscopy has been widely used for cancer diagnosis, but conventional forms provide limited depth information. Spatially offset Raman spectroscopy (SORS) can solve the depth issue, but it has only been used to detect hard tissues such as bone. We explore the feasibility of using SORS to discriminate two layers of soft tissue. Measurements were taken with individual source and detector fibers at a number of spatial offsets from samples consisting of various thicknesses of normal human breast tissues overlying breast tumors. Results show that SORS can detect tumors beneath normal tissue, marking, to the best of our knowledge, the first application of SORS for discriminating two layers of soft tissue.

© 2009 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.4730) Medical optics and biotechnology : Optical pathology
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 3, 2008
Manuscript Accepted: January 17, 2009
Published: March 18, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Matthew D. Keller, Shovan K. Majumder, and Anita Mahadevan-Jansen, "Spatially offset Raman spectroscopy of layered soft tissues," Opt. Lett. 34, 926-928 (2009)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. M. D. Keller, E. M. Kanter, and A. Mahadevan-Jansen, Spectroscopy 21, 33 (2006).
  2. P. Matousek, I. P. Clark, E. R. Draper, M. D. Morris, A. E. Goodship, N. Everall, M. Towrie, W. F. Finney, and A. W. Parker, Appl. Spectrosc. 59, 393 (2005). [CrossRef] [PubMed]
  3. P. Matousek, E. R. Draper, A. E. Goodship, I. P. Clark, K. L. Ronayne, and A. W. Parker, Appl. Spectrosc. 60, 758 (2006). [CrossRef] [PubMed]
  4. M. V. Schulmerich, K. A. Dooley, M. D. Morris, T. M. Vanasse, and S. A. Goldstein, J. Biomed. Opt. 11, 060502 (2006). [CrossRef]
  5. N. A. Macleod, A. Goodship, A. W. Parker, and P. Matousek, Anal. Chem. 80, 8146 (2008). [CrossRef] [PubMed]
  6. N. Stone, R. Baker, K. Rogers, A. W. Parker, and P. Matousek, Analyst (Cambridge, U.K.) 132, 899 (2007). [CrossRef]
  7. K. C. Horst, M. C. Smitt, D. R. Goffinet, and R. W. Carlson, Clin. Breast Cancer 5, 425 (2005). [CrossRef] [PubMed]
  8. N. Cabioglu, K. K. Hunt, A. A. Sahin, H. M. Kuerer, G. V. Babiera, S. E. Singletary, G. J. Whitman, M. I. Ross, F. C. Ames, B. W. Feig, T. A. Buchholz, and F. Meric-Bernstam, Ann. Surg. Oncol. 14, 1458 (2007). [CrossRef] [PubMed]
  9. C. M. Krishna, J. Kurien, S. Mathew, L. Rao, K. Maheedhar, K. K. Kumar, and M. Chowdary, Expert. Rev. Mol. Diagn. 8, 149 (2008). [CrossRef] [PubMed]
  10. S. K. Majumder, M. D. Keller, M. C. Kelley, F. I. Boulos, and A. Mahadevan-Jansen, J. Biomed. Opt. 13, 054009 (2008). [CrossRef] [PubMed]
  11. C. A. Lieber and A. Mahadevan-Jansen, Appl. Spectrosc. 57, 1363 (2003). [CrossRef] [PubMed]
  12. S. Srinivasan, M. Schulmerich, J. H. Cole, K. A. Dooley, J. M. Kreider, B. W. Pogue, M. D. Morris, and S. A. Goldstein, Opt. Express 16, 12190 (2008). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1 Fig. 2 Fig. 3
Fig. 4

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited