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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 7 — Apr. 1, 2009
  • pp: 953–955

Scanning fiber-optic nonlinear endomicroscopy with miniature aspherical compound lens and multimode fiber collector

Yicong Wu, Jiefeng Xi, Michael J. Cobb, and Xingde Li  »View Author Affiliations

Optics Letters, Vol. 34, Issue 7, pp. 953-955 (2009)

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A flexible scanning fiber-optic endomicroscope using a miniature compound lens and a multimode-fiber (MMF) collector was developed for two-photon fluorescence (TPF) and second-harmonic generation (SHG) imaging. The compound lens consisted of a pair of aspherical lenses and exhibited reduced chromatic aberration compared with gradient-index lenses, thus increasing the TPF/SHG collection efficiency. The introduction of a short MMF collector at the distal end of the double-clad fiber of the endomicroscope further mitigated the adverse influence of chromatic aberration of the lens and enhanced the TPF/SHG collection efficiency. Both ray-tracing simulations and experiments on TPF imaging of fluorescent beads and SHG imaging of rattail tendon demonstrated approximately nine (approximately four) times improved collection efficiency for TPF (SHG) with the new endomicroscope design that utilized a compound lens and an MMF collector.

© 2009 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(190.0190) Nonlinear optics : Nonlinear optics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 17, 2008
Revised Manuscript: February 4, 2009
Manuscript Accepted: February 5, 2009
Published: March 19, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Yicong Wu, Jiefeng Xi, Michael J. Cobb, and Xingde Li, "Scanning fiber-optic nonlinear endomicroscopy with miniature aspherical compound lens and multimode fiber collector," Opt. Lett. 34, 953-955 (2009)

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  1. W. R. Zipfel, R. M. Williams, R. Christie, A. Y. Nikitin, B. T. Hyman, and W. W. Webb, Proc. Natl. Acad. Sci. U.S.A. 100, 7075 (2003). [CrossRef] [PubMed]
  2. F. Helmchen, M. S. Fee, D. W. Tank, and W. Denk, Neuron 31, 903 (2001). [CrossRef] [PubMed]
  3. B. A. Flusberg, J. C. Jung, E. D. Cocker, E. P. Anderson, and M. J. Schnitzer, Opt. Lett. 30, 2272 (2005). [CrossRef] [PubMed]
  4. M. T. Myaing, D. J. MacDonald, and X. D. Li, Opt. Lett. 31, 1076 (2006). [CrossRef] [PubMed]
  5. L. Fu, A. Jain, H. Xie, C. Cranfield, and M. Gu, Opt. Express 14, 1027 (2006). [CrossRef] [PubMed]
  6. L. Fu, A. Jain, C. Cranfield, H. K. Xie, and M. Gu, J. Biomed. Opt. 12, 040501 (2007) [CrossRef] [PubMed]
  7. X. Liu, M. J. Cobb, Y. Chen, M. B. Kimmey, and X. D. Li, Opt. Lett. 29, 1763-1765 (2004) [CrossRef] [PubMed]
  8. P. J. Campagnola, A. C. Millard, M. Terasaki, P. E. Hoppe, C. J. Malone, and W. A. Mohler, Biophys. J. 82, 493 (2002). [CrossRef]

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