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Optics Letters

Optics Letters


  • Editor: Alan E. Willner
  • Vol. 34, Iss. 9 — May. 1, 2009
  • pp: 1435–1437

Are quantitative attenuation measurements of blood by optical coherence tomography feasible?

Dirk J. Faber and Ton G. van Leeuwen  »View Author Affiliations

Optics Letters, Vol. 34, Issue 9, pp. 1435-1437 (2009)

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We present optical coherence tomography (OCT) measurements on fully physiologically oxygenated blood samples of varying hematocrit. We show that attenuation coefficients cannot be extracted quantitatively using the currently accepted models for the OCT signal from scattering media, because the confidence intervals obtained in the fitting procedure cannot be used as reliable uncertainty estimates of the attenuation coefficients. Better modeling of the hematocrit-dependent OCT signal is needed.

© 2009 Optical Society of America

OCIS Codes
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 24, 2008
Revised Manuscript: March 24, 2009
Manuscript Accepted: April 2, 2009
Published: April 28, 2009

Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics

Dirk J. Faber and Ton G. van Leeuwen, "Are quantitative attenuation measurements of blood by optical coherence tomography feasible?," Opt. Lett. 34, 1435-1437 (2009)

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  1. D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 28, 1436 (2003). [CrossRef] [PubMed]
  2. D. J. Faber, M. C. G. Aalders, E. G. Mik, B. A. Hooper, M. J. C. van Gemert, and T. G. van Leeuwen, Phys. Rev. Lett. 93, 028102 (2004). [CrossRef] [PubMed]
  3. D. J. Faber, E. G. Mik, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Lett. 30, 1015 (2005). [CrossRef] [PubMed]
  4. J. M. Schmitt, S. H. Xiang, and K. M. Yung, J. Opt. Soc. Am. A 15, 2288 (1998). [CrossRef]
  5. U. Morgner, W. Drexler, F. X. Kärtner, X. D. Li, C. Pitris, E. P. Ippen, and J. G. Fujimoto, Opt. Lett. 25, 111 (2000). [CrossRef]
  6. R. Leitgeb, M. Wojtkowski, A. Kowalczyk, C. K. Hitzenberger, M. Sticker, and A. F. Fercher, Opt. Lett. 25, 820 (2000). [CrossRef]
  7. C. Lu, C. Lee, M. Tsai, Y. Wang, and C. C. Yang, Opt. Lett. 33, 416 (2008). [CrossRef] [PubMed]
  8. L. Kagemann and G. Wollstein, J. Biomed. Opt. 12, 041212 (2007). [CrossRef] [PubMed]
  9. A. Roggan, M. Friebel, K. Dorschel, A. Hahn, and G. Muller, J. Biomed. Opt. 4, 36 (1999). [CrossRef]
  10. M. Friebel, A. Roggan, G. Muller, and M. Meinke, J. Biomed. Opt. 11, 034021 (2006). [CrossRef]
  11. A. Amelink, D. J. Robinson, and H. J. C. M. Sterenborg, J. Biomed. Opt. 13, 054044 (2008). [CrossRef] [PubMed]
  12. D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. G. van Leeuwen, Opt. Express 12, 4353 (2004). [CrossRef] [PubMed]
  13. L. Thrane, H. T. Yura, and P. E. Andersen, J. Opt. Soc. Am. A 17, 484 (2000). [CrossRef]
  14. D. Levitz, L. Thrane, M. H. Frosz, P. E. Andersen, C. B. Andersen, S. Andersson-Engels, J. Valanciunaite, J. Swartling, and P. R. Hansen, Opt. Express 12, 249 (2004). [CrossRef] [PubMed]
  15. F. J. van der Meer, D. J. Faber, J. Peree, G. Pasterkamp, D. Baraznji Sassoon, and T. G. van Leeuwen, Lasers Med. Sci. 20, 45 (2005). [CrossRef] [PubMed]

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