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Optics Letters

| RAPID, SHORT PUBLICATIONS ON THE LATEST IN OPTICAL DISCOVERIES

  • Editor: Alan E. Willner
  • Vol. 34, Iss. 9 — May. 1, 2009
  • pp: 1483–1485

Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis

Kee-Hak Lim, Saira Salahuddin, Le Qiu, Hui Fang, Edward Vitkin, Ionita C. Ghiran, Mark D. Modell, Tamara Takoudes, Irving Itzkan, Eugene B. Hanlon, Benjamin P. Sachs, and Lev T. Perelman  »View Author Affiliations


Optics Letters, Vol. 34, Issue 9, pp. 1483-1485 (2009)
http://dx.doi.org/10.1364/OL.34.001483


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Abstract

Present techniques for prenatal diagnosis are invasive and present significant risks of fetal loss. Noninvasive prenatal diagnosis utilizing fetal nucleated red blood cells (fNRBC) circulating in maternal peripheral blood has received attention, since it poses no risk to the fetus. However, because of the failure to find broadly applicable identifiers that can differentiate fetal from adult NRBC, reliable detection of viable fNRBC in amounts sufficient for clinical use remains a challenge. In this Letter we show that fNRBC light-scattering spectroscopic signatures may lead to a clinically useful method of minimally invasive prenatal genetic testing.

© 2009 Optical Society of America

OCIS Codes
(170.1530) Medical optics and biotechnology : Cell analysis
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(280.1350) Remote sensing and sensors : Backscattering

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: February 23, 2009
Revised Manuscript: April 7, 2009
Manuscript Accepted: April 10, 2009
Published: April 30, 2009

Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Kee-Hak Lim, Saira Salahuddin, Le Qiu, Hui Fang, Edward Vitkin, Ionita C. Ghiran, Mark D. Modell, Tamara Takoudes, Irving Itzkan, Eugene B. Hanlon, Benjamin P. Sachs, and Lev T. Perelman, "Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis," Opt. Lett. 34, 1483-1485 (2009)
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-34-9-1483


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