We demonstrate high-harmonic generation in ${\mathrm{H}}_2\mathrm{O}$ using 800 and $1300\mathrm{nm}$ laser pulses up to a maximum intensity of $5\times {10}^{14}\mathrm{W}/{\mathrm{cm}}^2$ . Under optimal phase-matching conditions, photon energies up to ~60 and ~87 eV are produced by using 800 and $1300\mathrm{nm}$ light, respectively. The harmonic spectra in ${\mathrm{H}}_2\mathrm{O}$ , when compared with Xe with a similar ionization potential, exhibit significant extension of the cutoff region, indicating suppression of ionization arising from molecular orbital symmetry.